PLASMA BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS OF PATIENTS UNDERGOING HEMODIALYSIS AND PERITONEAL DIALYSIS

Abstract

Recent studies have shown that brain-derived neurotrophic factor (BDNF) is associated with neurotoxic, inflammatory and nutritional status. The purpose of this study is to investigate the changes in plasma BDNF concentration that were induced by chronic uremic condition. Using an enzyme-linked immunosorbent assay (ELISA), we measured peripheral BDNF levels in pre-hemodialysis (pre-HD), peritoneal dialysis (PD) patients and in a control group. The plasma BDNF concentrations of pre-HD, PD patients were significantly higher compared with those of controls (856.3±879.1, 1167.9±647.5 versus 403.1±288.9 pg/ml, respectively). The plasma BDNF in dialysis patients was positively correlated with high-sensitivity C reactive protein (hs-CRP) and with serum albumin negatively. Plasma BDNF hs-CRP Albumin r p r p Pre-HD 0.321 0.025 -0.298 0.021 PD 0.414 0.070 -0.527 0.008 Pre-HD + PD 0.446 0.001 -0.453 0.001 In conclusion, BDNF might plays some role in the neurotoxicity of uremia and associated with inflammation and malnutrition in dialysis patients.