Sensors (Oct 2012)

Interface Design for CMOS-Integrated Electrochemical Impedance Spectroscopy (EIS) Biosensors

  • Arjang Hassibi,
  • Arun Manickam,
  • Christopher Andrew Johnson,
  • Sam Kavusi

DOI
https://doi.org/10.3390/s121114467
Journal volume & issue
Vol. 12, no. 11
pp. 14467 – 14488

Abstract

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Electrochemical Impedance Spectroscopy (EIS) is a powerful electrochemical technique to detect biomolecules. EIS has the potential of carrying out label-free and real-time detection, and in addition, can be easily implemented using electronic integrated circuits (ICs) that are built through standard semiconductor fabrication processes. This paper focuses on the various design and optimization aspects of EIS ICs, particularly the bio-to-semiconductor interface design. We discuss, in detail, considerations such as the choice of the electrode surface in view of IC manufacturing, surface linkers, and development of optimal bio-molecular detection protocols. We also report experimental results, using both macro- and micro-electrodes to demonstrate the design trade-offs and ultimately validate our optimization procedures.

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