MicroRNAs and Natural Compounds Mediated Regulation of TGF Signaling in Prostate Cancer

Zeeshan Javed; Khushbukhat Khan; Amna Rasheed; Haleema Sadia; Shahid Raza; Bahare Salehi; William C. Cho; Javad Sharifi-Rad; Javad Sharifi-Rad; Wojciech Koch; Wirginia Kukula-Koch; Anna Głowniak-Lipa; Paweł Helon

doi:10.3389/fphar.2020.613464

Frontiers in Pharmacology (Jan 2021)

MicroRNAs and Natural Compounds Mediated Regulation of TGF Signaling in Prostate Cancer

Zeeshan Javed,
Khushbukhat Khan,
Amna Rasheed,
Haleema Sadia,
Shahid Raza,
Bahare Salehi,
William C. Cho,
Javad Sharifi-Rad,
Javad Sharifi-Rad,
Wojciech Koch,
Wirginia Kukula-Koch,
Anna Głowniak-Lipa,
Paweł Helon

Affiliations

Zeeshan Javed: Office for Research Innovation and Commercialization, Lahore Garrison University, Lahore, Pakistan
Khushbukhat Khan: Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan
Amna Rasheed: School of Basic Medical Sciences, Lanzhou University, Lanzhou, China
Haleema Sadia: Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan
Shahid Raza: Office for Research Innovation and Commercialization, Lahore Garrison University, Lahore, Pakistan
Bahare Salehi: Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
William C. Cho: Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China
Javad Sharifi-Rad: Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Javad Sharifi-Rad: Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Wojciech Koch: Chair and Department of Food and Nutrition, Medical University of Lublin, Lublin, Poland
Wirginia Kukula-Koch: 0Department of Pharmacognosy, Medical University of Lublin, Lublin, Poland
Anna Głowniak-Lipa: 1Department of Cosmetology, University of Information Technology and Management in Rzeszów, Rzeszów, Poland
Paweł Helon: 2Branch in Sandomierz, Jan Kochanowski University in Kielce, Sandomierz, Poland

DOI: https://doi.org/10.3389/fphar.2020.613464
Journal volume & issue: Vol. 11

Abstract

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Prostate cancer (PCa) is with rising incidence in male population globally. It is a complex anomaly orchestrated by a plethora of cellular processes. Transforming growth factor-beta (TGF-β) signaling is one of the key signaling pathways involved in the tumorigenesis of PCa. TGF-β signaling has a dual role in the PCa, making it difficult to find a suitable therapeutic option. MicroRNAs (miRNAs) mediated regulation of TGF-β signaling is responsible for the TGF-ß paradox. These are small molecules that modulate the expression of target genes and regulate cancer progression. Thus, miRNAs interaction with different signaling cascades is of great attention for devising new diagnostic and therapeutic options for PCa. Natural compounds have been extensively studied due to their high efficacy and low cytotoxicity. Here, we discuss the involvement of TGF-ß signaling in PCa with the interplay between miRNAs and TGF-β signaling and also review the role of natural compounds for the development of new therapeutics for PCa.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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