Generation of a non-integrated induced pluripotent stem cell line (SMBCi009-A) from urine-derived cells of a Chinese Familial hypercholesterolemia patient

Zijuan Qi; Yazhou Cui; Liang Shi; Jing Wang; Qingyang Zhao; Jing Luan; Jinxiang Han

Stem Cell Research (Mar 2022)

Generation of a non-integrated induced pluripotent stem cell line (SMBCi009-A) from urine-derived cells of a Chinese Familial hypercholesterolemia patient

Zijuan Qi,
Yazhou Cui,
Liang Shi,
Jing Wang,
Qingyang Zhao,
Jing Luan,
Jinxiang Han

Affiliations

Zijuan Qi: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, China
Yazhou Cui: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, China
Liang Shi: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, China
Jing Wang: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, China
Qingyang Zhao: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, China
Jing Luan: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, China
Jinxiang Han: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji’nan, Shandong, China; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji’nan, Shandong, China; Key Lab for Biotech-Drugs of National Health Commission, China; Key Lab for Rare & Uncommon Diseases of Shandong Province, China; Corresponding author at: Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University, Ji'nan, Shandong, China.

Journal volume & issue: Vol. 59
p. 102624

Abstract

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Familial hypercholesterolemia (FH; OMIM: # 143890) is a common inherited autosomal dominant disease, characterized by high-level low-density lipoprotein cholesterol (LDL-C) in plasma. Elevated LDL-C levels is closely related with atherosclerotic plaques and premature cardiovascular disease if not treated in time. Here we generated an induced pluripotent stem cell (iPSC) line using urine cells (UCs) derived from an 8-year-old male FH patient who carrying two coding and pathogenic mutations of low-density lipoprotein receptor (LDLR) gene (exon12:c.C1747T and exon13: c. 1948 del G). This induced pluripotent stem cell line named SMBCi009-A can be used to understand more cellular details about FH.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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