DNA‐organic molecular amphiphiles: Synthesis, self‐assembly, and hierarchical aggregates
Zhiyong Zhao,
Yuanchen Dong,
Zongze Duan,
Dou Jin,
Wei Yuan,
Dongsheng Liu
Affiliations
Zhiyong Zhao
Key Laboratory of Coal Conversion and New Carbon Material of Hubei Province School of Chemistry and Chemical Engineering Wuhan University of Science and Technology Wuhan Hubei PR China
Yuanchen Dong
CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics Beijing National Laboratory for Molecular Sciences Institute of Chemistry, Chinese Academy of Sciences Beijing PR China
Zongze Duan
Key Laboratory of Coal Conversion and New Carbon Material of Hubei Province School of Chemistry and Chemical Engineering Wuhan University of Science and Technology Wuhan Hubei PR China
Dou Jin
Key Laboratory of Coal Conversion and New Carbon Material of Hubei Province School of Chemistry and Chemical Engineering Wuhan University of Science and Technology Wuhan Hubei PR China
Wei Yuan
CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics Beijing National Laboratory for Molecular Sciences Institute of Chemistry, Chinese Academy of Sciences Beijing PR China
Dongsheng Liu
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Department of Chemistry Tsinghua University Beijing PR China
Abstract With the development of deoxyribonucleic acid (DNA) nanotechnology, various DNA nanostructures and DNA devices have been constructed, which exhibit potential applications in material science and biomedicine. Taking advantage of the programmability and biocompatibility of DNA, novel building block to chemically functionalize DNA with hydrophobic organic molecules has attracted more and more attention. Driving by amphiphilicity, DNA‐organic molecular amphiphiles have been demonstrated to self‐assemble or further induce hierarchically assemblies, providing novel‐specific properties. In this minireview, we summarize the recent progress of DNA organic molecular amphiphiles including their synthesis, self‐assembly behavior in aqueous solution, and the amphiphilic self‐assembly based on hierarchical DNA nano‐structures. We further briefly discuss the perspective of the application of the DNA‐organic molecular amphiphiles.
