Phylogenetic Analysis of the Nucleotide Sequences of the Uge Gene Detected in <i>Klebsiella pneumoniae</i> Strains

Abstract

Relevance. Klebsiella pneumoniae strains may have different virulence factor genes and cause nosological forms such as pneumonia, urinary tract infection, liver abscess, and neonatal sepsis. The purpose of this work is to conduct a phylogenetic analysis of the nucleotide sequences of the uge gene detected in K. pneumoniae strains. The purpose of this work is to conduct a phylogenetic analysis of the nucleotide sequences of the uge gene detected in K. pneumoniae strains. Materials & Methods. A total of 66 bacterial cultures identified in 2019 were examined. 45 bacterial cultures were isolated from fecal samples, 20 - from cervical canal samples, 1 - from the pharynx. Results. The uge gene was detected in 60.61% of Klebsiella pneumoniae strains isolated during bacteriological screening. Conclusions. The Klebsiella pneumoniae nucleotide sequences of the uge gene obtained in the course of this study differ from the analogous ones belonging to hypervirulent strains, which can be used to assess the pathogenic potential of isolates detected in hospitals and the epidemic situation in medical departments, as well as to develop approaches to predict the incidence rate of Klebsiella etiology infections based on molecular epidemiology methods.

Keywords

• <i>klebsiella pneumoniae</i>
• phylogenetic analysis
• uge gene