Latest advances in the study of non-coding RNA-mediated circadian rhythm disorders causing endometrial cancer

Ling-tao Zheng; Shao-rong Chen; Liang-yu Zhou; Qiao-yi Huang; Jia-ming Chen; Wei-hong Chen; Shu Lin; Shu Lin; Qi-yang Shi

doi:10.3389/fonc.2023.1277543

Frontiers in Oncology (Nov 2023)

Latest advances in the study of non-coding RNA-mediated circadian rhythm disorders causing endometrial cancer

Ling-tao Zheng,
Shao-rong Chen,
Liang-yu Zhou,
Qiao-yi Huang,
Jia-ming Chen,
Wei-hong Chen,
Shu Lin,
Shu Lin,
Qi-yang Shi

Affiliations

Ling-tao Zheng: Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
Shao-rong Chen: Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
Liang-yu Zhou: Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
Qiao-yi Huang: Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
Jia-ming Chen: Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
Wei-hong Chen: Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
Shu Lin: Centre of Neurological and Metabolic Research, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China
Shu Lin: Group of Neuroendocrinology, Garvan Institute of Medical Research, Sydney, NSW, Australia
Qi-yang Shi: Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China

DOI: https://doi.org/10.3389/fonc.2023.1277543
Journal volume & issue: Vol. 13

Abstract

Read online

Endometrial cancer (EC) is one of the most common gynecological cancers, and its risk factors include obesity and metabolic, genetic, and other factors. Recently, the circadian rhythm has also been shown to be associated with EC, as the severity of EC was found to be related to night work and rhythm disorders. Therefore, circadian rhythm disorders (CRDs) may be one of the metabolic diseases underlying EC. Changes in the circadian rhythm are regulated by clock genes (CGs), which in turn are regulated by non-coding RNAs (ncRNAs). More importantly, the mechanism of EC caused by ncRNA-mediated CRDs is gradually being unraveled. Here, we review existing studies and reports and explore the relationship between EC, CRDs, and ncRNAs.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

About the journal

Abstract

Keywords