Serum IgE Antibody Level in Iraqi Patients with Various Atopic Respiratory Diseases: A Narrative Review

Abstract

 Immunoglobulin E (IgE) is an antibody class that is unique to mammals, it is regarded as the last of the five classes of human immunoglobulins which was discovered in 1968 and it is widely linked to various numbers of allergic illnesses. Basophils, intestinal epithelial cells, antigen presenting cells, tissue mast cells as well as airway epithelial cells all express IgE receptor on its surface. The cell-degranulation signal, release of inflammatory allergic mediators and hypersensitivity responses, all begin with the cross-linking of allergen to receptor-bound IgE. IgE plays an important role in type I hypersensitivity, which is demonstrated as allergic asthma and various allergenic disorders, for example, sinusitis and chronic urticaria. In non-allergic people, serum IgE levels are relatively low (0.05 mg/ml). Remarkably, there is evidence of a relationship between whole IgE values and environmental and host variables. Regardless of sensitivity to frequent allergies or other allergy manifestations, population studies have found a link between the frequency of various allergies and serum total IgE levels.

Keywords

• atopic diseases
• asthma
• eosinophil count
• serum ige