Communications Biology (Feb 2021)

pH-dependent and dynamic interactions of cystatin C with heparan sulfate

  • Xiaoxiao Zhang,
  • Xinyue Liu,
  • Guowei Su,
  • Miaomiao Li,
  • Jian Liu,
  • Chunyu Wang,
  • Ding Xu

DOI
https://doi.org/10.1038/s42003-021-01737-7
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

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Zhang et al. identify Cystatin C as a new heparan sulfate (HS) binding protein, however only at acidic pH (≤6.5). They further identify two isolated HS binding motifs on Cystatin C that are required to come together to form a complete HS-binding site, which is a unique property among known HS binding proteins.