Targeting the signaling in Epstein–Barr virus-associated diseases: mechanism, regulation, and clinical study

Ya Cao; Longlong Xie; Feng Shi; Min Tang; Yueshuo Li; Jianmin Hu; Lin Zhao; Luqing Zhao; Xinfang Yu; Xiangjian Luo; Weihua Liao; Ann M. Bode

doi:10.1038/s41392-020-00376-4

Signal Transduction and Targeted Therapy (Jan 2021)

Targeting the signaling in Epstein–Barr virus-associated diseases: mechanism, regulation, and clinical study

Ya Cao,
Longlong Xie,
Feng Shi,
Min Tang,
Yueshuo Li,
Jianmin Hu,
Lin Zhao,
Luqing Zhao,
Xinfang Yu,
Xiangjian Luo,
Weihua Liao,
Ann M. Bode

Affiliations

Ya Cao: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University
Longlong Xie: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University
Feng Shi: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University
Min Tang: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University
Yueshuo Li: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University
Jianmin Hu: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University
Lin Zhao: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University
Luqing Zhao: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University
Xinfang Yu: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University
Xiangjian Luo: Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University
Weihua Liao: Department of Radiology, Xiangya Hospital, Central South University
Ann M. Bode: The Hormel Institute, University of Minnesota

DOI: https://doi.org/10.1038/s41392-020-00376-4
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 33

Abstract

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Abstract Epstein–Barr virus-associated diseases are important global health concerns. As a group I carcinogen, EBV accounts for 1.5% of human malignances, including both epithelial- and lymphatic-originated tumors. Moreover, EBV plays an etiological and pathogenic role in a number of non-neoplastic diseases, and is even involved in multiple autoimmune diseases (SADs). In this review, we summarize and discuss some recent exciting discoveries in EBV research area, which including DNA methylation alterations, metabolic reprogramming, the changes of mitochondria and ubiquitin-proteasome system (UPS), oxidative stress and EBV lytic reactivation, variations in non-coding RNA (ncRNA), radiochemotherapy and immunotherapy. Understanding and learning from this advancement will further confirm the far-reaching and future value of therapeutic strategies in EBV-associated diseases.

Published in Signal Transduction and Targeted Therapy

ISSN: 2059-3635 (Online)
Publisher: Nature Publishing Group
Country of publisher: United Kingdom
LCC subjects: Medicine; Science: Biology (General)
Website: http://www.nature.com/sigtrans/

About the journal