Trends in Azole Resistance in Aspergillus fumigatus, the Netherlands, 1994–2016

Abstract

We investigated azole resistance in Aspergillus fumigatus in a tertiary reference hospital in the Netherlands during 1994–2016. The 5-year patient-adjusted proportion of resistance increased from 0.79% for 1996–2001 to 4.25% for 2002–2006, 7.17% for 2007–2011, and 7.04% for 2012–2016. However, we observed substantial variation between years.

Keywords

• azole resistance
• Aspergillus fumigatus
• aspergillosis
• epidemiology
• antimicrobial resistance
• fungi