Molecules
(Jun 2020)
Lasianosides F–I: A New Iridoid and Three New Bis-Iridoid Glycosides from the Leaves of <i>Lasianthus verticillatus</i> (Lour.) Merr.
Gadah Abdulaziz Al-Hamoud,
Raha Saud Orfali,
Yoshio Takeda,
Sachiko Sugimoto,
Yoshi Yamano,
Nawal M. Al Musayeib,
Omer Ibrahim Fantoukh,
Musarat Amina,
Hideaki Otsuka,
Katsuyoshi Matsunami
Affiliations
Gadah Abdulaziz Al-Hamoud
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia
Raha Saud Orfali
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia
Yoshio Takeda
Faculty of Integrated Arts and Sciences, The University of Tokushima, 1-1 Minamijosanjima-Cho, Tokushima 770-8502, Japan
Sachiko Sugimoto
Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Yoshi Yamano
Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
Nawal M. Al Musayeib
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia
Omer Ibrahim Fantoukh
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia
Musarat Amina
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11495, Saudi Arabia
Hideaki Otsuka
Faculty of Pharmacy, Yasuda Women’s University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima 731-0153, Japan
Katsuyoshi Matsunami
Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan
DOI
https://doi.org/10.3390/molecules25122798
Journal volume & issue
Vol. 25,
no. 12
Abstract
Read online
A series of iridoid glycosides were isolated from the leaves of Lasianthus verticillatus (Lour.) Merr., belonging to family Rubiaceae. A new iridoid glycoside, lasianoside F (1), and three new bis-iridoid glycosides, lasianosides G–I (2–4), together with four known compounds (5–8) were isolated. The structures were established by spectroscopic methods, including 1D and 2D NMR experiments (1H, 13C, DEPT, COSY, HSQC, HMBC, and NOESY) in combination with HR-ESI-MS and CD spectra.
Keywords
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