Taxanes induced peripheral neuropathy: mechanism of development and pharmacogenetic factors

Abstract

For decades taxanes are used as a part of classical schemes for treatment of malignant tumors of various localizations including breast cancer. Peripheral neuropathy is an adverse reaction which impairs both quality of patients’ lives and treatment efficiency. To prevent or reduce the impact of peripheral neuropathy factors contributing to its development and mechanisms that are involved need to be known. This article is a review of the current status of our understanding about the mechanisms underlying the development of taxanes induced peripheral neuropathy.

Keywords

• cyp2c8 rs10509681
• rs11572080
• rs1058930
• abcb1 rs2032582
• taxanes
• neuropathy
• microtubules
• mitochondrial permeability transition pore
• pharmacogenetics
• cyp2c8 rs10509681
• rs11572080
• rs1058930
• abcb1 rs2032582