Nature Communications (Oct 2019)
Fungal dissemination is limited by liver macrophage filtration of the blood
- Donglei Sun,
- Peng Sun,
- Hongmei Li,
- Mingshun Zhang,
- Gongguan Liu,
- Ashley B. Strickland,
- Yanli Chen,
- Yong Fu,
- Juan Xu,
- Mohammed Yosri,
- Yuchen Nan,
- Hong Zhou,
- Xiquan Zhang,
- Meiqing Shi
Affiliations
- Donglei Sun
- Division of Immunology, Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland
- Peng Sun
- Division of Immunology, Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland
- Hongmei Li
- Division of Immunology, Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland
- Mingshun Zhang
- Division of Immunology, Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland
- Gongguan Liu
- Division of Immunology, Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland
- Ashley B. Strickland
- Division of Immunology, Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland
- Yanli Chen
- Division of Immunology, Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland
- Yong Fu
- Division of Immunology, Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland
- Juan Xu
- Division of Immunology, Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland
- Mohammed Yosri
- Division of Immunology, Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland
- Yuchen Nan
- Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University
- Hong Zhou
- Department of Immunology, Nanjing Medical University
- Xiquan Zhang
- Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University
- Meiqing Shi
- Division of Immunology, Virginia-Maryland College of Veterinary Medicine and Maryland Pathogen Research Institute, University of Maryland
- DOI
- https://doi.org/10.1038/s41467-019-12381-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Patients with liver diseases are at increased risk of fungal infections. Here the authors show that Kupffer cells are critical for the filtration of fungi out of the blood and thereby for liver-mediated protection against disseminating fungal infection.
