CORRELATION BETWEEN Β-HYDROXYBUTYRATE (Β-OHB) CONCENTRATION AND BICARBONATE LEVEL IN EARLY REGULATION OF BLOOD SUGAR ON DIABETIC KETOACIDOSIS PATIENTS IN RSUD DR. SAIFUL ANWAR MALANG, INDONESIA

Abstract

One of the acute complications of diabetes mellitus is diabetic ketoacidosis (DKA). DKA is characterized by glucose levels ≥14mmol/l (≥250mg/dL), acidosis pH <7.3, bicarbonate (HCO3) <18mEq/L, ketonemia, ketonuria. Currently in RSUD dr. Saiful Anwar, there is a β-hydroxybutyrate (β-OHB) examination by using a POCT ketone meter to facilitate clinical diagnosis and monitoring of DKA patients. The aim of this research is to analyze the correlation between the level of β-OHB and HCO3 on initial insulin regulation in DKA patients. The research method used is observational analytic, cross-sectional in which the data is retrieved in time series. A total of 15 subjects are included in the inclusion criteria. Research shows that there is a correlation between HCO3 and β-OHB levels after initial insulin regulation (p = 0.012 and r = −0.628). There were significant differences in the levels of HCO3, β-OHB before and after insulin regulation with p-value of 0.001 and 0.015, respectively. There is a match between HCO3 and β-OHB after insulin regulation (p = 0.250). It can be concluded that HCO3 and β-OHB in the administration of initial insulin regulation correlate strongly. Thus, β-OHB can be used instead of HCO3.

Keywords

• Diabetic ketoacidosis
• β-hydroxybutyrate
• bicarbonate
• insulin