Nature Communications (Mar 2021)

Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions

  • Feng Wang,
  • Bryant Chau,
  • Sean M. West,
  • Christopher R. Kimberlin,
  • Fei Cao,
  • Flavio Schwarz,
  • Barbara Aguilar,
  • Minhua Han,
  • Winse Morishige,
  • Christine Bee,
  • Gavin Dollinger,
  • Arvind Rajpal,
  • Pavel Strop

DOI
https://doi.org/10.1038/s41467-021-21563-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 9

Abstract

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Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) and GITR ligand (GITRL) regulate immune cell activities, including anti-tumor immune responses. Structures and visualization of human and mouse GITR–GITRL complexes offer insight into the architecture of higher-order membrane assemblies, and their signaling.