Control of non-REM sleep by ventrolateral medulla glutamatergic neurons projecting to the preoptic area

Sasa Teng; Fenghua Zhen; Li Wang; Jose Canovas Schalchli; Jane Simko; Xinyue Chen; Hao Jin; Christopher D. Makinson; Yueqing Peng

doi:10.1038/s41467-022-32461-3

Nature Communications (Aug 2022)

Control of non-REM sleep by ventrolateral medulla glutamatergic neurons projecting to the preoptic area

Sasa Teng,
Fenghua Zhen,
Li Wang,
Jose Canovas Schalchli,
Jane Simko,
Xinyue Chen,
Hao Jin,
Christopher D. Makinson,
Yueqing Peng

Affiliations

Sasa Teng: Institute for Genomic Medicine, Vagelos College of Physicians and Surgeons, Columbia University
Fenghua Zhen: Institute for Genomic Medicine, Vagelos College of Physicians and Surgeons, Columbia University
Li Wang: Zuckerman Mind Brain Behavior Institute, Department of Biochemistry and Molecular Biophysics, Columbia University
Jose Canovas Schalchli: Zuckerman Mind Brain Behavior Institute, Department of Biochemistry and Molecular Biophysics, Columbia University
Jane Simko: Institute for Genomic Medicine, Vagelos College of Physicians and Surgeons, Columbia University
Xinyue Chen: Institute for Genomic Medicine, Vagelos College of Physicians and Surgeons, Columbia University
Hao Jin: Zuckerman Mind Brain Behavior Institute, Department of Biochemistry and Molecular Biophysics, Columbia University
Christopher D. Makinson: Institute for Genomic Medicine, Vagelos College of Physicians and Surgeons, Columbia University
Yueqing Peng: Institute for Genomic Medicine, Vagelos College of Physicians and Surgeons, Columbia University

DOI: https://doi.org/10.1038/s41467-022-32461-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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In this study, Teng et al. identify a population of glutamatergic neurons in the ventrolateral medulla that control Non-Rapid Eye Movement (NREM) sleep in mice. They uncover an excitatory brainstem-hypothalamic circuit that controls wake-sleep transitions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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