Non-ionizing radiation-induced cellular senescence and age-related diseases

Abstract

Cellular senescence has emerged as an important contributor to aging and age-related diseases. Non-ionizing radiation (NIR), including ultraviolet radiation and electromagnetic fields, has been increasingly recognized as a key inducer of premature senescence. In this review, we discuss the molecular mechanisms of NIR-induced cellular senescence and its effects on aging and age-related diseases. We also summarize the modulation strategies for NIR-induced cellular senescence. A better understanding of the complex relationship between non-ionizing radiation, cellular senescence and age-related pathology may lead to interventions to ameliorate radiation damage and delay aging. Further research is still needed to elucidate the precise mechanisms, dose-response effects, and to develop protective strategies against radiation-induced senescence.

Keywords

• Non-ionizing radiation
• Cellular senescence
• Aging
• Age-related diseases
• DNA damage
• Oxidative stress