Perinatal inflammation influences but does not arrest rapid immune development in preterm babies

S. Kamdar; R. Hutchinson; A. Laing; F. Stacey; K. Ansbro; M. R. Millar; K. Costeloe; W. G. Wade; P. Fleming; D. L. Gibbons

doi:10.1038/s41467-020-14923-8

Nature Communications (Mar 2020)

Perinatal inflammation influences but does not arrest rapid immune development in preterm babies

S. Kamdar,
R. Hutchinson,
A. Laing,
F. Stacey,
K. Ansbro,
M. R. Millar,
K. Costeloe,
W. G. Wade,
P. Fleming,
D. L. Gibbons

Affiliations

S. Kamdar: Peter Gorer Department of Immunobiology, King’s College London
R. Hutchinson: Department of Neonatology, Homerton University Hospital
A. Laing: Peter Gorer Department of Immunobiology, King’s College London
F. Stacey: Department of Neonatology, Homerton University Hospital
K. Ansbro: Barts and the London School of Medicine and Dentistry, Queen Mary University of London
M. R. Millar: Barts and the London School of Medicine and Dentistry, Queen Mary University of London
K. Costeloe: Barts and the London School of Medicine and Dentistry, Queen Mary University of London
W. G. Wade: Faculty of Dentistry, Oral and Craniofacial Sciences, Centre for Host-Microbiome Interactions, King’s College London
P. Fleming: Department of Neonatology, Homerton University Hospital
D. L. Gibbons: Peter Gorer Department of Immunobiology, King’s College London

DOI: https://doi.org/10.1038/s41467-020-14923-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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The infant immune system is continuously shaped by environmental factors. Here the authors demonstrate that rapid immune development in preterm babies is modulated by perinatal inflammation more than gut microbiota, and that lower CXCL8-producing T cells may identify infants susceptible to infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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