Human Parvovirus 4 as Potential Cause of Encephalitis in Children, India

Abstract

To investigate whether uncharacterized infectious agents were associated with neurologic disease, we analyzed cerebrospinal fluid specimens from 12 children with acute central nervous system infection. A high-throughput pyrosequencing screen detected human parvovirus 4 DNA in cerebrospinal fluid of 2 children with encephalitis of unknown etiology.

Keywords

• viruses
• human parvovirus
• high throughput sequencing
• PARV4
• encephalitis
• epidemiology