Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Hongbin He; Hua Jiang; Yun Chen; Jin Ye; Aoli Wang; Chao Wang; Qingsong Liu; Gaolin Liang; Xianming Deng; Wei Jiang; Rongbin Zhou

doi:10.1038/s41467-018-04947-6

Nature Communications (Jun 2018)

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Hongbin He,
Hua Jiang,
Yun Chen,
Jin Ye,
Aoli Wang,
Chao Wang,
Qingsong Liu,
Gaolin Liang,
Xianming Deng,
Wei Jiang,
Rongbin Zhou

Affiliations

Hongbin He: Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Hua Jiang: Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Yun Chen: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen
Jin Ye: Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Aoli Wang: High Magnetic Field Laboratory, Chinese Academy of Sciences
Chao Wang: Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Qingsong Liu: High Magnetic Field Laboratory, Chinese Academy of Sciences
Gaolin Liang: Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China
Xianming Deng: State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen
Wei Jiang: Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Rongbin Zhou: Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-018-04947-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

Read online

The small molecule oridonin (Ori) from the traditional Chinese herb Rabdosia rubescens has anti-inflammatory activity. Here the authors show that Ori can be covalently linked to NLRP3 to prevent assembly of the NLRP3 inflammasome, and to ameliorate inflammation in several mouse disease models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal