Nature Communications (Sep 2019)
Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line
- Artem Vorobyev,
- Yask Gupta,
- Tanya Sezin,
- Hiroshi Koga,
- Yannic C. Bartsch,
- Meriem Belheouane,
- Sven Künzel,
- Christian Sina,
- Paul Schilf,
- Heiko Körber-Ahrens,
- Foteini Beltsiou,
- Anna Lara Ernst,
- Stanislav Khil’chenko,
- Hassanin Al-Aasam,
- Rudolf A. Manz,
- Sandra Diehl,
- Moritz Steinhaus,
- Joanna Jascholt,
- Phillip Kouki,
- Wolf-Henning Boehncke,
- Tanya N. Mayadas,
- Detlef Zillikens,
- Christian D. Sadik,
- Hiroshi Nishi,
- Marc Ehlers,
- Steffen Möller,
- Katja Bieber,
- John F. Baines,
- Saleh M. Ibrahim,
- Ralf J. Ludwig
Affiliations
- Artem Vorobyev
- Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Yask Gupta
- Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Tanya Sezin
- Department of Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Hiroshi Koga
- Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Yannic C. Bartsch
- Laboratories of Immunology and Antibody Glycan Analysis, Institute for Nutritional Medicine, University of Lübeck and University Medical Center Schleswig-Holstein
- Meriem Belheouane
- Max Planck Institute for Evolutionary Biology
- Sven Künzel
- Max Planck Institute for Evolutionary Biology
- Christian Sina
- Institute of Nutritional Medicine, Molecular Gastroenterology, University of Lübeck, Ratzeburger Allee 160
- Paul Schilf
- Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Heiko Körber-Ahrens
- Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Foteini Beltsiou
- Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Anna Lara Ernst
- Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Stanislav Khil’chenko
- Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Hassanin Al-Aasam
- Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Rudolf A. Manz
- Institute for Systemic Inflammation Research, University of Lübeck
- Sandra Diehl
- Department of Dermatology, Venereology and Allergology, Goethe University
- Moritz Steinhaus
- Laboratories of Immunology and Antibody Glycan Analysis, Institute for Nutritional Medicine, University of Lübeck and University Medical Center Schleswig-Holstein
- Joanna Jascholt
- Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Phillip Kouki
- Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Wolf-Henning Boehncke
- Divison of Dermatology and Venereology, Geneva University Hospitals, and Department of Pathology and Immunology, University of Geneva
- Tanya N. Mayadas
- Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
- Detlef Zillikens
- Department of Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Christian D. Sadik
- Department of Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Hiroshi Nishi
- Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School
- Marc Ehlers
- Laboratories of Immunology and Antibody Glycan Analysis, Institute for Nutritional Medicine, University of Lübeck and University Medical Center Schleswig-Holstein
- Steffen Möller
- Institute for Biostatistics and Informatics in Medicine and Ageing Research
- Katja Bieber
- Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- John F. Baines
- Max Planck Institute for Evolutionary Biology
- Saleh M. Ibrahim
- Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- Ralf J. Ludwig
- Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck
- DOI
- https://doi.org/10.1038/s41467-019-11952-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Complex traits associate with genetic variation and environment and their interaction. Here, the authors study the influence of different diets on trait variability in 1154 outbred mice from an advanced intercross line and find gene-diet interactions associated with spontaneous autoimmunity development in these animals.
