The Efficacy of Intralesional Injection of Glucantime with Mesotherapy for the Treatment of Cutanuos Leishmaniasis in Comparison to Classic Method

Abstract

• Background: Cutaneuos leishmaniasis is a common parasitic disease in 88 countries. Iran is one of the hyperendemic regions of cutaneuos lieshmaniasis. Mesotherapy is a technique used to deliver medication to a specific area of the body to treat a specific condition. This is done by painless multiple intradermal microinjections. • Methods: In this clinical trial study, 90 patients with confirmed cutaneuos lieshmaniasis in Isfahan Lieshmaniasis Research Center, were selected and randomly divided into 2 groups. Group A and B were treated by classic intralesional and mesotherapy injection respectively; intralesional injection of glucantime once a week for a maximum of 6 weeks was done for both groups. Patients were followed one week, one month and 3 months after the treatment. P value < 0.05 was considered as significant level. • Results: Sixty patients completed the study. There was no significant difference between the mean of changes of disease indecies of the lesions (size of ulcer, erythema and induration) in classic group and mesotherapy group. The speed of the lesion-cure regarding cure of ulcer, erythema and induration in the mesotherapy group was significantly less than classic group. The mean value of pain severity and the mean volume of the drug needed for each centimeter of the lesions in Mesotherapy group was significantly less than classic group. The results showed no statistical significant difference between the clinical and parasitological cure rate of the two groups. • Conclusion: Intralesional injection of glucantime by mesutherapy was more rapid, painless and cost effective than the classic method. This could promote the compliance of patients in the treatments procedure.

Keywords

• Cutaneuos lieshmaniasis
• Glucantime
• Mesotherapy