Majalah Kedokteran Bandung (Mar 2019)
Comparison between Use of Antibiotics and Argentum (Ag) in Infected Wound Healing
Abstract
Infected wound is a common problem encountered in the field of Orthopedics. Various procedures have been applied in order to achieve the effective treatment for wound infection. However, until recently, the biomolecular responses to those remain unclear. This study aimed to compare the effectiveness of antibiotics and argentum in infected wound healing by analyzing the FGF-2 and FGF-7 expressions; fibroblasts; bacteria colonization; and wound contraction rate during the proliferation phase of wound healing. This study was performed from May to September 2016 at the Pharmacology Research Laboratory, Faculty of Medicine, Padjadjaran University. A randomized clinical laboratory experimental trial with repetitive measures was performed in male rabbits that had been wounded and inoculated by 0.5 MF Staphylococcus aureus. Sample was collected before(Day 6) and after (Day 14) the application of antibiotics and argentum. The consecutive sampling method was used to determine the two treatment groups: (I) antibiotic group and (II) argentum group. The argentum group showed higher FGF-2 protein level, FGF-7 protein level, fibroblast count, and wound contraction rate with p<0.05 when compared to the antibiotic group. The use of argentum gave excellent responses to wound repair as indicated by elevated FGF-2 and FGF-7 levels; fibroblast counts; and wound contraction rate. The combination of both treatments might give synergistic responses and better results in healing infected wound. Argentum is more effective than antibiotics to increase the FGF-2 and FGF-7 levels; fibroblasts count; and wound contraction rate in the proliferative phase of infected wound healing. Antibiotics are more effective than argentum to decrease bacteria colonization. Key words: Bacteria colonization, FGF-2 protein, FGF-7 protein, fibroblast count, wound contraction rate
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