Nature Communications (May 2018)

B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation

  • Benjamin G. Barwick,
  • Christopher D. Scharer,
  • Ryan J. Martinez,
  • Madeline J. Price,
  • Alexander N. Wein,
  • Robert R. Haines,
  • Alexander P. R. Bally,
  • Jacob E. Kohlmeier,
  • Jeremy M. Boss

DOI
https://doi.org/10.1038/s41467-018-04234-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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DNA methylation is known to contribute to B cell differentiation, but de novo methylation has not been studied in this context. Here the authors use a conditional Dnmt3a/b knockout mouse to map the function of de novo DNA methylation in B cell differentiation and the development of humoral immunity.