Deconvolution of malignant pleural effusions immune landscape unravels a novel macrophage signature associated with worse clinical outcome in lung adenocarcinoma patients

• Gennaro Ciliberto,
• Luigi Aurisicchio,
• Matteo Pallocca,
• Maria Laura Foddai,
• Christian Napoli,
• Maurizio Fanciulli,
• Francesca De Nicola,
• Federico Venuta,
• Sara Bruschini,
• Eleonora Sperandio,
• Lorenzo D’Ambrosio,
• Francesca Ascenzi,
• Claudia De Vitis,
• Valentina Salvati,
• Antonella Esposito,
• Simona Di Martino,
• Francesca Paolini,
• Luigi Fattore,
• Gabriele Alessandrini,
• Francesco Facciolo,
• Massimiliano Bassi,
• Michela D’Ascanio,
• Alberto Ricci,
• Antonio D’ Andrilli,
• Erino Angelo Rendina,
• Rita Mancini

Affiliations

Gennaro Ciliberto

Scientific Direction, IRCCS Regina Elena National Cancer Institute, Rome, Italy

Luigi Aurisicchio

Aff5 Takis Rome Italy

Matteo Pallocca

5 SAFU Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy

Maria Laura Foddai

Immunohematology and Transfusional Medicine Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy

Christian Napoli

4 Department of Medical Surgical Sciences and Translational Medicine, Sapienza University of Rome, Roma, Lazio, Italy

Maurizio Fanciulli

SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, Istituto Regina Elena Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy, Italy

Francesca De Nicola

4 SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, IRCCS Regina Elena National Cancer Institute, Rome, Italy

Federico Venuta

1Department of Thoracic Surgery, University of Rome Sapienza, Rome, Italy

Sara Bruschini

Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy

Eleonora Sperandio

Biostatistics, Bioinformatics and Clinical Trial Center, IRCCS Regina Elena National Cancer Institute, Rome, Italy

Lorenzo D’Ambrosio

Tumor Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy

Francesca Ascenzi

Department of Clinical and Molecular Medicine, Sant` Andrea Hospital-Sapienza University of Rome, Rome, Italy

Claudia De Vitis

Department of Clinical and Molecular Medicine, Sant` Andrea Hospital-Sapienza University of Rome, Rome, Italy

Valentina Salvati

Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy

Antonella Esposito

Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, Catanzaro, Italy

Simona Di Martino

Pathology Unit, IRCCS-Regina Elena National Cancer Institute, Rome, Italy

Francesca Paolini

Tumor Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy

Luigi Fattore

SAFU Laboratory, IRCCS Regina Elena National Cancer Institute, Rome, Italy

Gabriele Alessandrini

Thoracic Surgery Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy

Francesco Facciolo

Thoracic Surgery Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy

Massimiliano Bassi

Thoracic Surgery Unit, Sapienza University of Rome, Rome, Italy

Michela D’Ascanio

Department of Clinical and Molecular Medicine, Sant` Andrea Hospital-Sapienza University of Rome, Rome, Italy

Alberto Ricci

Department of Clinical and Molecular Medicine, Sant` Andrea Hospital-Sapienza University of Rome, Rome, Italy

Antonio D’ Andrilli

Thoracic Surgery Unit, Sant` Andrea Hospital-Sapienza University of Rome, Rome, Italy

Erino Angelo Rendina

Thoracic Surgery Unit, Sant` Andrea Hospital-Sapienza University of Rome, Rome, Italy

Rita Mancini

Department of Clinical and Molecular Medicine, Sant` Andrea Hospital-Sapienza University of Rome, Rome, Italy