Nature Communications (Jan 2016)

Replication landscape of the human genome

  • Nataliya Petryk,
  • Malik Kahli,
  • Yves d'Aubenton-Carafa,
  • Yan Jaszczyszyn,
  • Yimin Shen,
  • Maud Silvain,
  • Claude Thermes,
  • Chun-Long Chen,
  • Olivier Hyrien

DOI
https://doi.org/10.1038/ncomms10208
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

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The physical origin and termination sites of DNA replication in human cells have remained elusive. Here the authors use Okazaki fragment sequencing to reveal global replication patterns and show how chromatin and transcription modulate the process.