IgD attenuates the IgM-induced anergy response in transitional and mature B cells

Zahra Sabouri; Samuel Perotti; Emily Spierings; Peter Humburg; Mehmet Yabas; Hannes Bergmann; Keisuke Horikawa; Carla Roots; Samantha Lambe; Clara Young; T. Dan Andrews; Matthew Field; Anselm Enders; Joanne H. Reed; Christopher C. Goodnow

doi:10.1038/ncomms13381

Nature Communications (Nov 2016)

IgD attenuates the IgM-induced anergy response in transitional and mature B cells

Zahra Sabouri,
Samuel Perotti,
Emily Spierings,
Peter Humburg,
Mehmet Yabas,
Hannes Bergmann,
Keisuke Horikawa,
Carla Roots,
Samantha Lambe,
Clara Young,
T. Dan Andrews,
Matthew Field,
Anselm Enders,
Joanne H. Reed,
Christopher C. Goodnow

Affiliations

Zahra Sabouri: Department of Immunology, John Curtin School of Medical Research, The Australian National University
Samuel Perotti: Department of Immunology, John Curtin School of Medical Research, The Australian National University
Emily Spierings: Department of Immunology, John Curtin School of Medical Research, The Australian National University
Peter Humburg: Immunology Division, The Garvan Institute of Medical Research
Mehmet Yabas: Department of Immunology, John Curtin School of Medical Research, The Australian National University
Hannes Bergmann: Department of Immunology, John Curtin School of Medical Research, The Australian National University
Keisuke Horikawa: Department of Immunology, John Curtin School of Medical Research, The Australian National University
Carla Roots: Department of Immunology, John Curtin School of Medical Research, The Australian National University
Samantha Lambe: Department of Immunology, John Curtin School of Medical Research, The Australian National University
Clara Young: Department of Immunology, John Curtin School of Medical Research, The Australian National University
T. Dan Andrews: Department of Immunology, John Curtin School of Medical Research, The Australian National University
Matthew Field: Department of Immunology, John Curtin School of Medical Research, The Australian National University
Anselm Enders: Department of Immunology, John Curtin School of Medical Research, The Australian National University
Joanne H. Reed: Immunology Division, The Garvan Institute of Medical Research
Christopher C. Goodnow: Department of Immunology, John Curtin School of Medical Research, The Australian National University

DOI: https://doi.org/10.1038/ncomms13381
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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Self-reactive B cells that are anergic express mainly IgD, yet the function of IgD is not clear. Here the authors analyse primary B cells from mice to show that IgD signalling attenuates self-antigen induced gene expression and promotes survival of anergic B cells that might go on to reactivate to foreign antigens and mutate away from self-reactivity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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