Nature Communications (Nov 2021)
ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation
- Yan Gu,
- Yanrong Chen,
- Lai Wei,
- Shuang Wu,
- Kaicheng Shen,
- Chengxiang Liu,
- Yan Dong,
- Yang Zhao,
- Yue Zhang,
- Chi Zhang,
- Wenling Zheng,
- Jiangyi He,
- Yunlong Wang,
- Yifei Li,
- Xiaoxin Zhao,
- Hongwei Wang,
- Jun Tan,
- Liting Wang,
- Qi Zhou,
- Ganfeng Xie,
- Houjie Liang,
- Juanjuan Ou
Affiliations
- Yan Gu
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Yanrong Chen
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Lai Wei
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Shuang Wu
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Kaicheng Shen
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Chengxiang Liu
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Yan Dong
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Yang Zhao
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Yue Zhang
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Chi Zhang
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Wenling Zheng
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Jiangyi He
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Yunlong Wang
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Yifei Li
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Xiaoxin Zhao
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Hongwei Wang
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Jun Tan
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Liting Wang
- Biomedical Analysis Center, Third Military Medical University (Army Medical University)
- Qi Zhou
- Department of Oncology, Fuling Central Hospital of Chongqing City
- Ganfeng Xie
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Houjie Liang
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- Juanjuan Ou
- Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University)
- DOI
- https://doi.org/10.1038/s41467-021-26967-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
This study reveals an unrecognized role of ABHD5 in regulating colon cancer stemness via controlling YAP methylation and nuclear localization, further explaining the molecular mechanism through which ABHD5 functions as a tumour suppressor gene in colon cancer.
