mBio
(Feb 2021)
Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway
Xuefeng Jiang,
Tian Tang,
Jinfeng Guo,
Yuhang Wang,
Peipei Li,
Xiangjun Chen,
Lily Wang,
Yiqun Wen,
Junli Jia,
Garbarino Emanuela,
Benshun Hu,
Shuhua Chen,
Kun Yao,
Linyun Li,
Huaming Tang
Affiliations
Xuefeng Jiang
Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Tian Tang
Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Jinfeng Guo
Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Yuhang Wang
Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Peipei Li
Department of Women’s Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, People’s Republic of China
Xiangjun Chen
Department of Women’s Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, People’s Republic of China
Lily Wang
Department of Women’s Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, People’s Republic of China
Yiqun Wen
Department of Women’s Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, People’s Republic of China
Junli Jia
Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Garbarino Emanuela
Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Benshun Hu
Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Shuhua Chen
Department of Critical Care Medicine, Changzhou Cancer Hospital Affiliated to Soochow University, Changzhou, People’s Republic of China
Kun Yao
Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Linyun Li
Department of Medical Genetics, Nanjing Medical University, Nanjing, People’s Republic of China
Huaming Tang
ORCiD Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
DOI
https://doi.org/10.1128/mBio.03505-20
Journal volume & issue
Vol. 12,
no. 1
Abstract
Read online
HHV-6B (human herpesvirus 6B) is well known to evade host antiviral responses and establish a lifelong latent infection. How HHV-6B evades RNA recognition is still poorly understood. Our results indicate that HHV-6 U26 plays a vital role in RLR/MAVS signaling pathway activity. Knockout of endogenous MAVS could facilitate HHV-6B replication. The findings in this study could provide new insights into host-virus interactions and help develop a new therapy against HHV-6B infection.
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