Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway

Xuefeng Jiang; Tian Tang; Jinfeng Guo; Yuhang Wang; Peipei Li; Xiangjun Chen; Lily Wang; Yiqun Wen; Junli Jia; Garbarino Emanuela; Benshun Hu; Shuhua Chen; Kun Yao; Linyun Li; Huaming Tang

doi:10.1128/mBio.03505-20

mBio (Feb 2021)

Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway

Xuefeng Jiang,
Tian Tang,
Jinfeng Guo,
Yuhang Wang,
Peipei Li,
Xiangjun Chen,
Lily Wang,
Yiqun Wen,
Junli Jia,
Garbarino Emanuela,
Benshun Hu,
Shuhua Chen,
Kun Yao,
Linyun Li,
Huaming Tang

Affiliations

Xuefeng Jiang: Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Tian Tang: Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Jinfeng Guo: Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Yuhang Wang: Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Peipei Li: Department of Women’s Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, People’s Republic of China
Xiangjun Chen: Department of Women’s Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, People’s Republic of China
Lily Wang: Department of Women’s Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, People’s Republic of China
Yiqun Wen: Department of Women’s Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, People’s Republic of China
Junli Jia: Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Garbarino Emanuela: Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Benshun Hu: Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Shuhua Chen: Department of Critical Care Medicine, Changzhou Cancer Hospital Affiliated to Soochow University, Changzhou, People’s Republic of China
Kun Yao: Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China
Linyun Li: Department of Medical Genetics, Nanjing Medical University, Nanjing, People’s Republic of China
Huaming Tang: ORCiD; Department of Immunology, Nanjing Medical University, Nanjing, People’s Republic of China

DOI: https://doi.org/10.1128/mBio.03505-20
Journal volume & issue: Vol. 12, no. 1

Abstract

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HHV-6B (human herpesvirus 6B) is well known to evade host antiviral responses and establish a lifelong latent infection. How HHV-6B evades RNA recognition is still poorly understood. Our results indicate that HHV-6 U26 plays a vital role in RLR/MAVS signaling pathway activity. Knockout of endogenous MAVS could facilitate HHV-6B replication. The findings in this study could provide new insights into host-virus interactions and help develop a new therapy against HHV-6B infection.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal