The Use of Ion Liquids as a Trojan Horse Strategy in Enzyme-Catalyzed Biotransformation of (<i>R</i>,<i>S</i>)-Atenolol

Abstract

The enzymatic method was used for the direct biotransformation of racemic atenolol. The catalytic activities of commercially available lipases from Candida rugosa were tested for the kinetic resolution of (R,S)-atenolol by enantioselective acetylation in various two-phase reaction media containing ionic liquids. The composed catalytic system gave the possibility to easy separate substrates and products of the conducted enantioselective reaction and after specific procedure to reuse utilized enzymes in another catalytic cycle.

Keywords

• kinetic resolution
• (<i>R</i>,<i>S</i>)-atenolol
• lipase
• ionic liquids
• enzyme-catalyzed biotransformation