Multicomponent Crystallization of Ketoprofen-nicotinamide for Improving the Solubility and Dissolution Rate

Abstract

The study was aimed at increasing solubility and dissolution rate of ketoprofen by using multicomponent crystallization approach with nicotinamide as additional material. The multicomponent crystallization was carried out by solvent evaporation method using 2-propanol as solvent. The solubility and dissolution test showed that the ketoprofen-nicotinamide multicomponent crystal has solubility and dissolution rate significantly higher than the solubility and dissolution rate of the pure ketoprofen.

Keywords

• ketoprofen
• multicomponent crystallization
• solvent evaporation
• solubility
• dissolution rate