From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications
Magdalena Miętus,
Krzysztof Kolankowski,
Tomasz Gołofit,
Piotr Denis,
Aleksandra Bandzerewicz,
Maciej Spychalski,
Marcin Mąkosa-Szczygieł,
Maciej Pilarek,
Kamil Wierzchowski,
Agnieszka Gadomska-Gajadhur
Affiliations
Magdalena Miętus
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3 Street, 00-664 Warsaw, Poland
Krzysztof Kolankowski
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3 Street, 00-664 Warsaw, Poland
Tomasz Gołofit
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3 Street, 00-664 Warsaw, Poland
Piotr Denis
Laboratory of Polymers and Biomaterials, Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B Street, 02-106 Warsaw, Poland
Aleksandra Bandzerewicz
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3 Street, 00-664 Warsaw, Poland
Maciej Spychalski
Faculty of Materials Science and Engineering, Warsaw University of Technology, Wołoska 141 Street, 02-507 Warsaw, Poland
Marcin Mąkosa-Szczygieł
Department of Chemistry, Faculty of Natural Sciences, Norwegian University of Science and Technology, 7034 Trondheim, Norway
Maciej Pilarek
Faculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1 Street, 00-645 Warsaw, Poland
Kamil Wierzchowski
Faculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1 Street, 00-645 Warsaw, Poland
Agnieszka Gadomska-Gajadhur
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3 Street, 00-664 Warsaw, Poland
Electrospinning is a process that has attracted significant interest in recent years. It provides the opportunity to produce nanofibers that mimic the extracellular matrix. As a result, it is possible to use the nonwovens as scaffolds characterized by high cellular adhesion. This work focused on the synthesis of poly(glycerol itaconate) (PGItc) and preparation of nonwovens based on PGItc gels and polylactide. PGItc gels were synthesized by a reaction between itaconic anhydride and glycerol. The use of a mixture of PGItc and PLA allowed us to obtain a material with different properties than with stand-alone polymers. In this study, we present the influence of the chosen ratios of polymers and the OH/COOH ratio in the synthesized PGItc on the properties of the obtained materials. The addition of PGItc results in hydrophilization of the nonwovens’ surface without disrupting the high porosity of the fibrous structure. Spectral and thermal analyzes are presented, along with SEM imagining. The preliminary cytotoxicity research showed that nonwovens were non-cytotoxic materials. It also helped to pre-determine the potential application of PGItc + PLA nonwovens as subcutaneous tissue fillers or drug delivery systems.
