Nature Communications (Jan 2016)

Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease

  • Qingde Zhou,
  • Allen Yen,
  • Grzegorz Rymarczyk,
  • Hirohide Asai,
  • Chelsea Trengrove,
  • Nadine Aziz,
  • Michael T. Kirber,
  • Gustavo Mostoslavsky,
  • Tsuneya Ikezu,
  • Benjamin Wolozin,
  • Victoria M. Bolotina

DOI
https://doi.org/10.1038/ncomms10332
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

Read online

PLA2g6 regulates store-operated Ca2+ entry and is linked to Parkinson’s disease. Here, Zhou et al find faulty PLA2g6-dependent Ca2+signaling in idiopathic PD patients, and show that its impairment triggers autophagic dysfunction and loss of dopaminergic neurons in a new PLA2g6 ex2KO mouse model.