Nature Communications (Jan 2021)

Whole genome sequencing of metastatic colorectal cancer reveals prior treatment effects and specific metastasis features

  • Pauline A. J. Mendelaar,
  • Marcel Smid,
  • Job van Riet,
  • Lindsay Angus,
  • Mariette Labots,
  • Neeltje Steeghs,
  • Mathijs P. Hendriks,
  • Geert A. Cirkel,
  • Johan M. van Rooijen,
  • Albert J. Ten Tije,
  • Martijn P. Lolkema,
  • Edwin Cuppen,
  • Stefan Sleijfer,
  • John W. M. Martens,
  • Saskia M. Wilting

DOI
https://doi.org/10.1038/s41467-020-20887-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Molecular landscapes of metastatic colorectal cancers (mCRC) have often been restricted to coding regions or low numbers of patients. Here the authors present a whole-genome landscape of 429 mCRC patients, revealing the mutational impact of prior therapies and potential actionable targets.