An institutional experience of early glottic cancers treated with radiotherapy

Abstract

Introduction: This retrospective study aimed at analyzing the recurrence rates in early glottic cancers (tumor, node, metastasis Stages I and II) treated at Gujarat Cancer and Research Institute (GCRI) from 2014 to 2018 by radiotherapy alone. Materials and Methods: The present study included 170 patients treated at GCRI from January 2014 to December 2018. One hundred and twenty-six patients were of stage T1N0, and rest 44 were of T2N0. Total radiotherapy dose received by them were 60 Gray in 30 fractions on linear accelerator with 6 MV photons without elective neck irradiation. Results: The mean duration of follow-up was 60 months. The local control (LC) rate was 93.65% in stage T1N0 stage and 84.1% in stage T2N0 glottic cancer. Out of the total 170 patients included in this study, 15 patients developed local recurrence which was biopsy proven, leading to overall local failure rate of 8.82%, and the mean time to recurrence as noted in our study was 9.1 months. Ultimate LC rate by radiotherapy alone was 91.2%. Conclusion: Radiotherapy provides better LC along with the advantage of organ preservation in T1N0 and T2N0 glottic cancer, and the local failure can be salvaged by surgery.

Keywords

• early stage
• glottic cancer
• hypofractionation
• institution experience
• radiation
• surgical salvage