The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence

Gang Wang; Jean-Michel Brunel; Matthias Preusse; Negar Mozaheb; Sven D. Willger; Gerald Larrouy-Maumus; Pieter Baatsen; Susanne Häussler; Jean-Michel Bolla; Françoise Van Bambeke

doi:10.1038/s42003-022-03836-5

Communications Biology (Aug 2022)

The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence

Gang Wang,
Jean-Michel Brunel,
Matthias Preusse,
Negar Mozaheb,
Sven D. Willger,
Gerald Larrouy-Maumus,
Pieter Baatsen,
Susanne Häussler,
Jean-Michel Bolla,
Françoise Van Bambeke

Affiliations

Gang Wang: Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain
Jean-Michel Brunel: Aix Marseille Université, INSERM, SSA, Membranes et Cibles thérapeutiques (MCT)
Matthias Preusse: Department of Molecular Bacteriology, Helmoltz Centre for Infection Research
Negar Mozaheb: Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain
Sven D. Willger: Department of Molecular Bacteriology, Helmoltz Centre for Infection Research
Gerald Larrouy-Maumus: Department of Life Sciences, Faculty of Natural Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College London
Pieter Baatsen: Electron Microscopy Platform & Bio Imaging Core, VIB & KULeuven Center for Brain & Disease Research, KULeuven
Susanne Häussler: Department of Molecular Bacteriology, Helmoltz Centre for Infection Research
Jean-Michel Bolla: Aix Marseille Université, INSERM, SSA, Membranes et Cibles thérapeutiques (MCT)
Françoise Van Bambeke: Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvain

DOI: https://doi.org/10.1038/s42003-022-03836-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 17

Abstract

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The polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics through permeabilizing the outer membrane and increases the activity of antibiotics on biofilms.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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