Association of impaired fasting glucose and Type 2 Diabetes Mellitus with brain volume changes in Alzheimer’s Disease patients analyzed by MRI: a retrospective study
Weiwei Wang,
Leongtim Wong,
Lin Shi,
Yishan Luo,
Zhanhua Liang,
Chunbo Dong,
Qingwei Song,
Tieli Liu,
Qing Zhang,
Ailian Liu,
Yanwei Miao,
Jianlin Wu
Affiliations
Weiwei Wang
Tianjin Medical University, Tianjin, China
Leongtim Wong
BrainNow Research Institute, Shenzhen, Guangdong Province, China
Lin Shi
Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China
Yishan Luo
BrainNow Research Institute, Shenzhen, Guangdong Province, China
Zhanhua Liang
Neurology Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
Chunbo Dong
Neurology Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
Qingwei Song
Radiology Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
Tieli Liu
Radiology Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
Qing Zhang
Radiology Department, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning Province, China
Ailian Liu
Radiology Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
Yanwei Miao
Radiology Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China
Jianlin Wu
Radiology Department, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning Province, China
Objectives Alzheimer’s disease (AD), impaired fasting glucose (IFG), and Type 2 diabetes mellitus (T2DM) were reported associated with smaller brain volumes. Nevertheless, the association of hyperglycemia with brain volume changes in AD patients remains unclear. To investigate this issue, structural magnetic resonance imaging was used to compare brain volumes among AD patients with different fasting glucose levels. Methods Eighty-five AD patients were divided into three groups based on their fasting glucose level as suggested by the American Diabetes Association: normal fasting glucose group (AD_NFG, n = 45), AD_IFG group (n = 15), and AD_T2DM group (n = 25). Sagittal 3D T1-weighted images were obtained to calculate the brain volume. Brain parenchyma and 33 brain structures were automatically segmented. Each regional volume was analyzed among groups. For regions with statistical significance, partial correlation analysis was used to evaluate their relationships with fasting glucose level, corrected for Mini-Mental State Examination score, age, education level, cholesterol, triglyceride, and blood pressure. Results Compared with the AD_IFG and AD_NFG groups, the volume of pons in AD_T2DM group was significantly smaller. Fasting glucose was negatively correlated with pontine volume. Conclusions T2DM may exacerbate pontine atrophy in AD patients, and fasting glucose level is associated with pontine volume.
