Uric acid levels are associated with severity and mortality in patients with acute coronary syndrome

Abstract

Acute coronary syndrome (ACS) causes a serious of coronary artery diseases that associated with sudden and reduced blood flow to the heart. The aim of this study was to assess the potential of serum uric acid (SUA) to predict severity and mortality in patients with ACS. According to their SUA levels, eligible participants were assigned into the Hyperuricemia group and the Normouricemia group (control group). All the patients were requested to enroll into a 1-year follow-up, and the final clinical outcomes included the SYNTAX and Gensini scores, major adverse cardiovascular events (MACEs), and cardiovascular mortality. In total, 874 participants were followed-up. Individuals with high levels of uric acid bore more disease vessels exhibited higher SYNTAX and Gensini scores. Besides, patients in the Hyperuricemia group showed elevated rates of MACE and cardiovascular mortality. High SUA level is positively associated with severity and mortality of patients with ACS. SUA might be a novel ACS prediction marker and risk factor in clinical diagnosis.

Keywords

• uric acid
• acute coronary syndromes
• prediction marker
• risk factor