Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient

Huan Xia; Yuanlin Guan; Silvère D. Zaongo; Han Xia; Ziyu Wang; Zhongfang Yan; Ping Ma

doi:10.3389/fneur.2019.01202

Frontiers in Neurology (Nov 2019)

Progressive Multifocal Leukoencephalopathy Diagnosed by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid in an HIV Patient

Huan Xia,
Yuanlin Guan,
Silvère D. Zaongo,
Han Xia,
Ziyu Wang,
Zhongfang Yan,
Ping Ma

Affiliations

Huan Xia: Department of Infectious Disease, Tianjin Second People's Hospital, Tianjin, China
Yuanlin Guan: Hugobiotech Co., Ltd, Beijing, China
Silvère D. Zaongo: Department of Infectious Disease, Tianjin Second People's Hospital, Tianjin, China
Han Xia: Hugobiotech Co., Ltd, Beijing, China
Ziyu Wang: Department of Infectious Disease, Tianjin Second People's Hospital, Tianjin, China
Zhongfang Yan: Department of Infectious Disease, Tianjin Second People's Hospital, Tianjin, China
Ping Ma: Department of Infectious Disease, Tianjin Second People's Hospital, Tianjin, China

DOI: https://doi.org/10.3389/fneur.2019.01202
Journal volume & issue: Vol. 10

Abstract

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Metagenomic next-generation sequencing (mNGS) is a novel approach to identify pathogens undetected by conventional methods. Herein, we report a case in which mNGS was used to identify JC virus from the cerebrospinal fluid sample of an HIV positive patient with progressive multifocal leukoencephalopathy (PML).

Published in Frontiers in Neurology

ISSN: 1664-2295 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://www.frontiersin.org/journals/neurology/

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