Death receptor 6 contributes to autoimmunity in lupus-prone mice

Daisuke Fujikura; Masahiro Ikesue; Tsutomu Endo; Satoko Chiba; Hideaki Higashi; Toshimitsu Uede

doi:10.1038/ncomms13957

Nature Communications (Jan 2017)

Death receptor 6 contributes to autoimmunity in lupus-prone mice

Daisuke Fujikura,
Masahiro Ikesue,
Tsutomu Endo,
Satoko Chiba,
Hideaki Higashi,
Toshimitsu Uede

Affiliations

Daisuke Fujikura: Division of Infection and Immunity, Hokkaido University Research Center for Zoonosis Control
Masahiro Ikesue: Division of Molecular Immunology, Hokkaido University Institute for Genetic Medicine
Tsutomu Endo: Division of Molecular Immunology, Hokkaido University Institute for Genetic Medicine
Satoko Chiba: Division of Infection and Immunity, Hokkaido University Research Center for Zoonosis Control
Hideaki Higashi: Division of Infection and Immunity, Hokkaido University Research Center for Zoonosis Control
Toshimitsu Uede: Division of Molecular Immunology, Hokkaido University Institute for Genetic Medicine

DOI: https://doi.org/10.1038/ncomms13957
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Germinal centre (GC) reactions are driven by T follicular helper (Tfh) cells and their dysregulation can cause autoimmune disease. Here the authors show that the orphan receptor DR6 is a Tfh cell marker that binds syndecan-1 on GC B cells driving autoimmunity in lupus-prone mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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