Dual-Role Ubiquitination Regulation Shuttling the Entire Life Cycle of the Flaviviridae

Dongjie Cai; Lingli Liu; Bin Tian; Xingxin Fu; Qiyuan Yang; Jie Chen; Yilin Zhang; Yilin Zhang; Jing Fang; Liuhong Shen; Ya Wang; Liping Gou; Zhicai Zuo

doi:10.3389/fmicb.2022.835344

Frontiers in Microbiology (May 2022)

Dual-Role Ubiquitination Regulation Shuttling the Entire Life Cycle of the Flaviviridae

Dongjie Cai,
Lingli Liu,
Bin Tian,
Xingxin Fu,
Qiyuan Yang,
Jie Chen,
Yilin Zhang,
Yilin Zhang,
Jing Fang,
Liuhong Shen,
Ya Wang,
Liping Gou,
Zhicai Zuo

Affiliations

Dongjie Cai: Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
Lingli Liu: Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
Bin Tian: Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
Xingxin Fu: Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
Qiyuan Yang: Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
Jie Chen: Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
Yilin Zhang: Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
Yilin Zhang: Laboratory of Animal Disease Prevention and Control Center, Agriculture and Rural Affairs Bureau of Luoping County, Luoping, China
Jing Fang: Department of Basic Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
Liuhong Shen: Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
Ya Wang: Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
Liping Gou: Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China
Zhicai Zuo: Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China

DOI: https://doi.org/10.3389/fmicb.2022.835344
Journal volume & issue: Vol. 13

Abstract

Read online

Ubiquitination is a reversible protein post-translational modification that regulates various pivotal physiological and pathological processes in all eukaryotes. Recently, the antiviral immune response is enhanced by the regulation of ubiquitination. Intriguingly, Flaviviridae viruses can ingeniously hijack the ubiquitination system to help them survive, which has become a hot topic among worldwide researchers. The Flaviviridae family members, such as HCV and CSFV, can cause serious diseases of humans and animals around the world. The multiple roles of ubiquitination involved in the life cycle of Flaviviridae family would open new sight for future development of antiviral tactic. Here, we discuss recent advances with regard to functional roles of ubiquitination and some ubiquitin-like modifications in the life cycle of Flaviviridae infection, shedding new light on the antiviral mechanism research and therapeutic drug development.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

About the journal

Abstract

Keywords