Microwave-assisted synthesis and antimicrobial evaluation of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-ols

Abstract

A new series of 6-[3-aryl-1-phenyl-4’,5’-dihydro[4,5’-bi-1H-pyrazol]-3’-yl]-2H-chromen-5-ol derivatives was synthesized by Michael addition of chalcones 5a–j with hydrazine hydrate in presence of sodium acetate under conventional heating and microwave irradiation. Structural assignment of the products was confirmed based on IR, 1H-NMR, 13C-NMR, MS and analytical data. All the synthesized compounds 6a–j were screened for their antimicrobial activity against various bacterial and fungal strains. Most of the compounds exhibited variable range of antimicrobial activity and compounds 6c–f and 6i showed promising antimicrobial potency.

Keywords

• pyrazole
• pyrazoline
• microwave irradiation
• antimicrobial activity