Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats

Luqiang Huang; Luqiang Huang; Luqiang Huang; Wenxin Wu; Linshan Huang; Jiaze Zhong; Lei Chen; Meiying Wang; Huibin Chen; Huibin Chen

doi:10.3389/fnut.2022.1003627

Frontiers in Nutrition (Sep 2022)

Antarctic krill (Euphausia superba) oil modulatory effects on ethanol-induced acute injury of the gastric mucosa in rats

Luqiang Huang,
Luqiang Huang,
Luqiang Huang,
Wenxin Wu,
Linshan Huang,
Jiaze Zhong,
Lei Chen,
Meiying Wang,
Huibin Chen,
Huibin Chen

Affiliations

Luqiang Huang: College of Life Science, Southern Institute of Oceanography, Fujian Normal University, Fuzhou, China
Luqiang Huang: The Public Service Platform for Industrialization Development Technology of Marine Biological Medicine and Product of State Oceanic Administration, Fujian Normal University, Fuzhou, China
Luqiang Huang: Marine Active Substance and Product Technology Research and Development Center of Ocean Research Institute of Fuzhou, Fujian Normal University, Fuzhou, China
Wenxin Wu: College of Life Science, Southern Institute of Oceanography, Fujian Normal University, Fuzhou, China
Linshan Huang: College of Life Science, Southern Institute of Oceanography, Fujian Normal University, Fuzhou, China
Jiaze Zhong: College of Life Science, Southern Institute of Oceanography, Fujian Normal University, Fuzhou, China
Lei Chen: College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, China
Meiying Wang: School of Engineering, University of Guelph, Guelph, ON, Canada
Huibin Chen: College of Life Science, Southern Institute of Oceanography, Fujian Normal University, Fuzhou, China
Huibin Chen: The Public Service Platform for Industrialization Development Technology of Marine Biological Medicine and Product of State Oceanic Administration, Fujian Normal University, Fuzhou, China

DOI: https://doi.org/10.3389/fnut.2022.1003627
Journal volume & issue: Vol. 9

Abstract

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Antarctic krill oil (KO) prepared using supercritical carbon dioxide extraction and characterized using gas chromatography-mass spectrometry was used to investigate its preventive effect on ethanol-induced gastric tissue damage in a rat model in vivo. KO characterization showed that 74.96% of the unsaturated fatty acids consist of oleic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Rats pre-treated with KO (100, 200, and 500 mg/kg) showed mitigated oxidative stress through enhanced antioxidant enzyme superoxide dismutase (SOD) and reducing enzymes malondialdehyde (MDA) and myeloperoxidase (MPO) in gastric mucosal injury induced by ethanol. Additionally, the secretion of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), the expression of the IκBα/NF-κB signaling pathway, and nitric oxide (NO) production was suppressed. The results also demonstrated a significant decrease in histological injury and hemorrhage scores in a dose-dependent manner in the KO range. Therefore, KO has potential as a food supplement to alleviate ethanol-induced acute gastric mucosal injury.

Published in Frontiers in Nutrition

ISSN: 2296-861X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.frontiersin.org/journals/nutrition/

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