Nature Communications (May 2022)

Cell cycle gene regulation dynamics revealed by RNA velocity and deep-learning

  • Andrea Riba,
  • Attila Oravecz,
  • Matej Durik,
  • Sara Jiménez,
  • Violaine Alunni,
  • Marie Cerciat,
  • Matthieu Jung,
  • Céline Keime,
  • William M. Keyes,
  • Nacho Molina

DOI
https://doi.org/10.1038/s41467-022-30545-8
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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Single-cell RNA-sequencing technology gives access to cell cycle dynamics without externally perturbing the cell. Here the authors present DeepCycle,a robust deep learning method to infer the cell cycle state in single cells from scRNA-seq data.