The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

Gabriel J. Starrett; Elizabeth M. Luengas; Jennifer L. McCann; Diako Ebrahimi; Nuri A. Temiz; Robin P. Love; Yuqing Feng; Madison B. Adolph; Linda Chelico; Emily K. Law; Michael A. Carpenter; Reuben S Harris

doi:10.1038/ncomms12918

Nature Communications (Sep 2016)

The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis

Gabriel J. Starrett,
Elizabeth M. Luengas,
Jennifer L. McCann,
Diako Ebrahimi,
Nuri A. Temiz,
Robin P. Love,
Yuqing Feng,
Madison B. Adolph,
Linda Chelico,
Emily K. Law,
Michael A. Carpenter,
Reuben S Harris

Affiliations

Gabriel J. Starrett: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota
Elizabeth M. Luengas: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota
Jennifer L. McCann: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota
Diako Ebrahimi: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota
Nuri A. Temiz: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota
Robin P. Love: Department of Microbiology and Immunology, University of Saskatchewan
Yuqing Feng: Department of Microbiology and Immunology, University of Saskatchewan
Madison B. Adolph: Department of Microbiology and Immunology, University of Saskatchewan
Linda Chelico: Department of Microbiology and Immunology, University of Saskatchewan
Emily K. Law: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota
Michael A. Carpenter: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota
Reuben S Harris: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota

DOI: https://doi.org/10.1038/ncomms12918
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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The APOBEC family of enzymes are cytidine deaminases with APOBEC3A and APOBEC3B thought to contribute to DNA damage signatures detected in cancer genomes. Here, the authors demonstrate an unappreciated role for APOBEC3H haplotype I in the generation of DNA damage in breast cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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