A Facile One-Pot Method for Synthesis of 2,4-Dichloroquinoline Derivatives

Abstract

A facile one-pot method with good yield for the synthesis of 2,4-dichloroquinoline and some related new derivatives by condensation of the appropriate primary aromatic amine with malonic acid in presence of excess phosphorus oxychloride is described.

Keywords

• 2,4-dichloro-7, 8-benzoquinoline
• 2,4-dichloroquinoline
• 2,4,6-trichloroquinoline bis(2, 4-dichloroquinoline)methane
• 2-chloro-1,8-naphtyridine-4-one