Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure

Lei Chen; Bilin Liu; Yuan Qin; Yuan Qin; Anqi Li; Meng Gao; Hanyu Liu; Guohua Gong; Guohua Gong

doi:10.3389/fmolb.2021.681237

Frontiers in Molecular Biosciences (May 2021)

Mitochondrial Fusion Protein Mfn2 and Its Role in Heart Failure

Lei Chen,
Bilin Liu,
Yuan Qin,
Yuan Qin,
Anqi Li,
Meng Gao,
Hanyu Liu,
Guohua Gong,
Guohua Gong

Affiliations

Lei Chen: Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
Bilin Liu: Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
Yuan Qin: Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
Yuan Qin: Department of Pharmacy, Shanghai East Hospital, Tongji University, Shanghai, China
Anqi Li: Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
Meng Gao: Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
Hanyu Liu: Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
Guohua Gong: Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China
Guohua Gong: Department of Gastroenterology, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China

DOI: https://doi.org/10.3389/fmolb.2021.681237
Journal volume & issue: Vol. 8

Abstract

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Mitofusin 2 (Mfn2) is a transmembrane GTPase located on the mitochondrial outer membrane that contributes to mitochondrial network regulation. It is an essential multifunctional protein that participates in various biological processes under physical and pathological conditions, including mitochondrial fusion, reticulum–mitochondria contacts, mitochondrial quality control, and apoptosis. Mfn2 dysfunctions have been found to contribute to cardiovascular diseases, such as ischemia-reperfusion injury, heart failure, and dilated cardiomyopathy. Here, this review mainly focuses on what is known about the structure and function of Mfn2 and its crucial role in heart failure.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

About the journal

Abstract

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