Cell Reports Medicine (Apr 2021)
Activated CD4+ T cells and CD14hiCD16+ monocytes correlate with antibody response following influenza virus infection in humans
- Sook-San Wong,
- Christine M. Oshansky,
- Xi-Zhi J. Guo,
- Jacqui Ralston,
- Timothy Wood,
- Gary E. Reynolds,
- Ruth Seeds,
- Lauren Jelley,
- Ben Waite,
- Trushar Jeevan,
- Mark Zanin,
- Marc-Alain Widdowson,
- Q. Sue Huang,
- Paul G. Thomas,
- Richard J. Webby,
- Nikki Turner,
- Michael Baker,
- Cameron Grant,
- Colin McArthur,
- Sally Roberts,
- Adrian Trenholmes,
- Conroy Wong,
- Susan Taylor,
- Mark Thompson,
- Diane Gross,
- Jazmin Duque,
- Kathryn Haven,
- Debbie Aley,
- Pamela Muponisi,
- Bhamita Chand,
- Yan Chen,
- Laurel Plewes,
- Frann Sawtell,
- Shirley Lawrence,
- Reniza Cogcoy,
- Jo Smith,
- Franie Gravidez,
- Mandy Ma,
- Shona Chamberlin,
- Kirstin Davey,
- Tania Knowles,
- Jo-Ann McLeish,
- Angela Todd,
- Judy Bocacao,
- Wendy Gunn,
- Pamela Kawakami,
- Susan Walker,
- Robyn Madge,
- Nicole Moore,
- Fahimeh Rahnama,
- Helen Qiao,
- Fifi Tse,
- Mahtab Zibaei,
- Tirzah Korrapadu,
- Louise Optland,
- Cecilia Dela Cruz
Affiliations
- Sook-San Wong
- State Key Laboratory for Respiratory Diseases, Guangzhou Medical University, 151 Dongfengxi Road, Yuexiu District, Guangzhou 510000, China; Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA; School of Public Health, The University of Hong Kong, 7 Sassoon Road, Pokfulam, Hong Kong SAR, China; Corresponding author
- Christine M. Oshansky
- Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA; Biomedical Advanced Research and Development Authority (BARDA), Office of the Assistant Secretary for Preparedness and Response (ASPR), US Department of Health and Human Services (DHHS), 200 C Street, SW, Washington, DC 20201, USA
- Xi-Zhi J. Guo
- Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Brigham and Women’s Hospital, 75 Francis Street, Boston, MA 02115, USA
- Jacqui Ralston
- Institute for Environmental Science and Research, NCBID Wallaceville, 66 Ward Street, Upper Hutt 5018, New Zealand
- Timothy Wood
- Institute for Environmental Science and Research, NCBID Wallaceville, 66 Ward Street, Upper Hutt 5018, New Zealand
- Gary E. Reynolds
- Immunisation Advisory Centre, University of Auckland, Auckland, New Zealand
- Ruth Seeds
- Institute for Environmental Science and Research, NCBID Wallaceville, 66 Ward Street, Upper Hutt 5018, New Zealand; Minsitry for Primary Industries, 66 Ward Street, Upper Hutt 5140, New Zealand
- Lauren Jelley
- Institute for Environmental Science and Research, NCBID Wallaceville, 66 Ward Street, Upper Hutt 5018, New Zealand
- Ben Waite
- Institute for Environmental Science and Research, NCBID Wallaceville, 66 Ward Street, Upper Hutt 5018, New Zealand
- Trushar Jeevan
- Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
- Mark Zanin
- State Key Laboratory for Respiratory Diseases, Guangzhou Medical University, 151 Dongfengxi Road, Yuexiu District, Guangzhou 510000, China; Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA; School of Public Health, The University of Hong Kong, 7 Sassoon Road, Pokfulam, Hong Kong SAR, China
- Marc-Alain Widdowson
- Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA; Institute of Tropical Medicine (ITM), Nationalestraat 155, 2000 Antwerp, Belgium
- Q. Sue Huang
- Institute for Environmental Science and Research, NCBID Wallaceville, 66 Ward Street, Upper Hutt 5018, New Zealand
- Paul G. Thomas
- Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Corresponding author
- Richard J. Webby
- Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA; Corresponding author
- Nikki Turner
- Michael Baker
- Cameron Grant
- Colin McArthur
- Sally Roberts
- Adrian Trenholmes
- Conroy Wong
- Susan Taylor
- Mark Thompson
- Diane Gross
- Jazmin Duque
- Kathryn Haven
- Debbie Aley
- Pamela Muponisi
- Bhamita Chand
- Yan Chen
- Laurel Plewes
- Frann Sawtell
- Shirley Lawrence
- Reniza Cogcoy
- Jo Smith
- Franie Gravidez
- Mandy Ma
- Shona Chamberlin
- Kirstin Davey
- Tania Knowles
- Jo-Ann McLeish
- Angela Todd
- Judy Bocacao
- Wendy Gunn
- Pamela Kawakami
- Susan Walker
- Robyn Madge
- Nicole Moore
- Fahimeh Rahnama
- Helen Qiao
- Fifi Tse
- Mahtab Zibaei
- Tirzah Korrapadu
- Louise Optland
- Cecilia Dela Cruz
- Journal volume & issue
-
Vol. 2,
no. 4
p. 100237
Abstract
Summary: The failure to mount an antibody response following viral infection or seroconversion failure is a largely underappreciated and poorly understood phenomenon. Here, we identified immunologic markers associated with robust antibody responses after influenza virus infection in two independent human cohorts, SHIVERS and FLU09, based in Auckland, New Zealand and Memphis, Tennessee, USA, respectively. In the SHIVERS cohort, seroconversion significantly associates with (1) hospitalization, (2) greater numbers of proliferating, activated CD4+ T cells, but not CD8+ T cells, in the periphery during the acute phase of illness, and (3) fewer inflammatory monocytes (CD14hiCD16+) by convalescence. In the FLU09 cohort, fewer CD14hiCD16+ monocytes during early illness in the nasal mucosa were also associated with the generation of influenza-specific mucosal immunoglobulin A (IgA) and IgG antibodies. Our study demonstrates that seroconversion failure after infection is a definable immunological phenomenon, associated with quantifiable cellular markers that can be used to improve diagnostics, vaccine efficacy, and epidemiologic efforts.
