Revista da Sociedade Brasileira de Medicina Tropical (Oct 2015)

Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant Enterococcus faecalis

  • Tiane Martin de Moura,
  • Fabrício Souza Campos,
  • Juliana Caierão,
  • Ana Claudia Franco,
  • Paulo Michel Roehe,
  • Pedro Alves d'Azevedo,
  • Jeverson Frazzon,
  • Ana Paula Guedes Frazzon

DOI
https://doi.org/10.1590/0037-8682-0017-2015
Journal volume & issue
Vol. 48, no. 5
pp. 617 – 621

Abstract

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ABSTRACTINTRODUCTION:Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome.METHODS: Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin.RESULTS:A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro .CONCLUSIONS:Subinhibitory concentrations of vancomycin may regulate the expression of virulence factors in vivo or contribute to the selection of vancomycin-resistant strains.

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